Publications

2023

  • Chang, WWJ.; Thies, A.; Tresguerres, M.; Hu, M.Y. Soluble adenylyl cyclase coordinates intracellular pH homeostasis and biomineralization in calcifying cells of a marine animal, American Journal of physiology, Cell Physiology. (in press)
  • Chou, P-H.; Hu, M.Y.; Guh, Y-J.; Wu, G-C.; Yang, S-H.; Tandon, K.; Shao, Y-T.; Lin, L-Y.;Chen, C.; Tseng, K-Y.; Wang, M-C.; Zhang, C-M.; Han, B-C.; Lin, C-C.; Tang, S-L.; Jeng, M-S.; Chang, C-F.; Tseng, Y-C. Cellular mechanisms underlying extraordinary sulfide tolerance in a crustacean holobiont from hydrothermal vents, Proceedings of the Royal Society B, 290:20221973 (Research Highlight in Nature doi: https://doi.org/10.1038/d41586-023-00035-y)

2022

  • Matt, A-S.; Chang, WWJ.; Hu, M.Y. Extracellular carbonic anhydrase activity promotes a carbon concentration mechanism in metazoan calcifying cells, Proceedings of the National Academy of Sciences of the U.S.A., 119:e2203904119

2021

  • Chang, WWJ.; Matt, A-S.; Schewe, M.; Musinski, M.; Grüssel, S.; Brandenburg, J.; Garfield, D.; Bleich, M.; Baukrowitz, T.; Hu, M.Y. An Otopetrin proton channel promotes cellular acid-efflux critical for biomineralization in a marine calcifier, Proceedings of the National Academy of Sciences of the U.S.A. 118: 30
  • Petersen, I.; Chang, WWJ.; Hu, M.Y. Na+/H+ exchangers differentially contribute to midgut fluid sodium and proton concentration in the sea urchin larva, Journal of Experimental Biology, 224, jeb240705

2020

  • Ramesh, K.; Hu, M.Y.; Melzner, F.;Bleich, M; Himmerkus, N. Intracellular pH regulation in mantle epithelial cells of the pacific oyser, Crassostrea gigas, Comparative Biochemistry and Physiology B, 190(6):691-700
  • Hu, M.Y.; Petersen, I.; Chang, W.; Blurton, C.; Stumpp, M. Cellular bicarbonate accumulation and vesicular proton transport promote calcification in the sea urchin larva, Proceedings of the Royal Society B 287: 20201506
  • Huang, P-C.; Liu, T-Y.; Hu, M.Y.; Casties, I.; Tseng, Y-C. Energy and nitrogenous waste from glutamate/glutamine catabolism facilitates acute osmotic adjustment in non-neuroectodermal branchial cells, Scientific Reports 10:9460
  • Hu, M.Y. Active ion transport mechanisms and their role for past, present and future life in marine systems, Journal of the Marine Biological Association of the United Kingdom  doi.org/10.1017/S0025315420000363
  • Stumpp, M.; Petersen, I.; Thoben, F.; Yan, J.-J.; Leippe, M.; Hu, M.Y. Alkaline guts contribute to immunity during exposure to acidified seawater in the sea urchin larva, Journal of Experimental Biology 223: jeb222844
  • Di Giglio, S.; Lein, E.; Hu, M.Y.; Stumpp, M.; Melzner, F.; Malet, L.; Pernet, P.; Dubois, P. Skeletal integrity of a marine keystone predator (Asterias rubens) threatened by ocean acidification, Journal of Experimental Marine Biology and Ecology 526:151335

2019

  • Lee, H-G.; Stumpp, M.; Yan, J-J.; Tseng, Y-C.; Heinzel, S.; Hu, M.Y. Tipping points of gastric pH regulation and energetics in the sea urchin larva exposed to CO2-induced seawater acidification, Comparative Bichemistry and Physiology A 234:87-97
  • Taubner, I.; Hu, M.Y.; Eisenhauer, A.; Bleich, M. Electrophysiological evidence for light activated cation transport in calcifying corals, Proceedings of the Royal Society B 286:20182444
  • Jurikova H.; Liebetrau, V.; Gutjahr M.; Rollion-Bard C.; Hu M.Y.; Krause S.; Henkel D.; Hiebenthal C.; Schmidt M.; Laudien J.; Eisenhauer A. Boron isotope systematics of cultured brachiopods: response to acidification, vital effects and implications for palaeo-pH reconstruction, Geochimica et Cosmochimica Acta 248:370-386
  • Stumpp, M.; Dupont, S.; Hu, M.Y. Measurement of feeding rates, respiration, and pH regulatory processes in the light of ocean acidification research. Foltz, K.R.; Hamdoun, A. (eds) Elsevier Academic Press
  • Sevilgen D.S.; Venn A.A.; Hu M.Y.; Tambutté E.; de Beer D.; Planas-Bielsa V.; Tambutté S. Full in vivo characterization of carbonate chemistry at the site of calcification in corals, Science Advances 5:eaau7447

2018

  • Hu M.Y.; Yan J.-J.; Petersen I.; Himmerkus N.; Bleich M.; Stumpp M. A SLC4 family bicarbonate transporter is critical for intracellular pH regulation and biomineralization in sea urchin embryos, elife 7:e36600
  • Hu M.Y.; Lein, E.; Bleich M.; Melzner F.; Stumpp M. Trans-life cycle acclimation to experimental ocean acidification affects gastric pH homeostasis and larval recruitment in the sea star Asterias rubens, Acta Physiologica 224(2):e13075

2017

  • Ramesh K.; Hu M.Y.; Thomsen J.; Bleich M., Melzner F. Mussel larvae modify calcifying fluid carbonate chemistry to counter ocean acidification, Nature Communications DOI: 10.1038/s41467-017-01806-8
  • Hu M.Y.; Tseng Y-C.; Lein E; Lee J-R.; Lee H-G.; Su Y-H; Dupont S; Stumpp M. (2017) Variability in larval gut pH regulation defines sensitivity to ocean acidification in six species of the ambulacraria superphylum, Proceedings of the Royal Society of London B 284:1864
  • Hu, M.Y; Sung, P-H; Guh, Y-J; Lee, J-R; Hwang, P-P.; Weihrauch, D.; Tseng, Y-C. (2017) Perfused gills reveal fundamental principles of pH regulation and ammonia homeostasis in the cephalopod Octopus vulgaris, Frontiers in Physiology 8:162

2016

  • Hu M.Y.; Michael ; Kreiss C.; Hwang P-P.; Dupont S.; Tseng Y-C.; Lucassen M. (2016) Temperature modulates the effects of ocean acidification on intestinal ion transport in Atlantic cod, Gadus morhua, Frontiers in Physiology 7:198
  • Hu M.Y. (2016) Effects of CO2 driven ocean acidification on ontogenetic stages of the cuttlefish Sepia officinalis. Vie et Milieu, Life and Environment (66:57-63)
  • Hu M.Y.; Guh Y-J; Hwang P-P.; Jeng M.-S.; Tseng Y-C. (2016) Strong ion regulatory abilities enable the crab Xenograpsus testudinatus to inhabit highly acidic hydrothermal vent systems. Frontiers in Physiology 7:14
  • Hu, MY; Tseng Y-C (2016) Acid-base balance in cephalopods. In: Acid-base balance and nitrogen excretion in invertebrates, Weihrauch, D. O´Donnell, M. (eds) Springer International Publishing Swizerland.
  • Stumpp, M; Hu, MY (2016) Acid-Base balance in Echinoderms. In: Acid-base balance and nitrogen excretion in invertebrates, Weihrauch, D. O´Donnell, M. (eds) Springer International Publishing Swizerland.

2015

  • SigwartD.; LyonsG.; FinkA.; GutowskaM.A.; MurrayD.; MelznerF.; Houghton J. D.R.; Hu M.Y. (2015) Ocean acidification drives lower growth and yet increased calcification in the early life history of the cuttlefish Sepia officinalis (Mollusca: Cephalopoda). ICES Journal of Marine Sciences 73 (3): 970-980
  • Michael ; Kreiss C.; Hu M.Y.; Koschnik N.; Bickmeyer U.; Dupont S.; Pörtner H.-O.; Lucassen M (2015) Adjustments of molecular key components of branchial ion and pH regulation in Atlantic cod (Gadus morhua) in response to ocean acidification and warming Comparative Biochemistry and Physiology B 193:33-46
  • Hu M.Y.; Hwang P.-P.; Tseng Y.-C. (2015) Recent advances in understanding trans epithelial acid-base regulation and excretion mechanisms in cephalopods. Tissue Barriers, 3:4 (Invited Review)
  • Stumpp M.1; Hu M.Y.1; Tseng Y-C.; Guh Y-J; Chen Y-C.; Yu J-K.; Su Y-H; Hwang P-P. (2015) Evolution of extreme stomach pH in bilateria inferred from gastric alkalization mechanisms in basal deuterostomes. Scientific Reports, 5:10421 (1 co-first author)

2014

  • Tseng Y-C.1; Liu S-T.1; Hu M.Y.1; Chen R-D.; Lee J-R.; Hwang P-P. (2014) Brain functioning under acute hypothermic stress supported by dynamic monocarboxylate utilization and transport in ectothermic fish. Frontiers in Zoology, 11:53 (1 co-first author)
  • Hu M.Y.; Lee J-R.; Stumpp M.; Guh Y-J; Hwang P-P.; Tseng Y-C. (2014) Branchial NH4+-dependent acid-base transport mechanisms and energy metabolism of squid (Sepioteuthis lessoniana) affected by seawater acidification. Frontiers in Zoology, 11:55
  • Hu M. Y.; Casties I.; Stumpp M.; Ortega-Martinez O.; Dupont (2014) Energy metabolism and regeneration impaired by seawater acidification in the infaunal brittlestar, Amphiura filiformis. The Journal of Experimental Biology, 217: 2411-2421

2013

  • Hu M.Y.; Lee J-R., Lin L-Y.; Shih T-H.; Stumpp M.; Lee M-F.; Hwang P-P.; Tseng Y-C. (2013) Development in a naturally acidified environment: Na+/H+-exchanger3-based proton secretion leads to CO2 tolerance in cephalopod embryos. Frontiers in Zoology, 10:51-67
  • Stumpp M.1; M.Y.1; Casties I.; Saborowski R.; Bleich M.; Melzner F.; Dupont S. (2013) Digestion in sea urchin larvae impaired under ocean acidification. Nature Climate Change, 3:1044-1049 (1 co-first author)
  • Tseng,-C.1; Hu M.Y.1; Stumpp M.; Li-Yih Lin, Frank Melzner and Pung-Pung Hwang (2013) CO2-driven seawater acidification differentially affects development and molecular plasticity along life history of fish (Oryzias latipes). Comparative Biochemistry and Physiology A, 165:119–130 (1equal contribution)

2012

  • Stumpp, M.1; Hu, M.Y.1; Melzner, F.; Dorey, N.; Himmerkus, N.; Gutowska, M.A.; Dupont, S.; Thorndyke, M.C.; Bleich, M. (2012) Acidified seawater impacts sea urchin larval pH regulatory systems relevant for calcification. Proceedings of the National Academy of Sciences of the U.S.A., 109:18192-18197 (1equal contribution)
  • Strobel A., Hu M. Y. Gutowska A.M., Lieb B., Lucassen M., Melzner F., Pörtner H.O., Mark F.C., (2012) Influence of temperature, hypercapnia and development on the relative expression of different haemocyanin isoforms in the common cuttlefish Sepia officinalis. Journal of Experimental Zoology Part A, 317:511-23
  • Hu M.Y., Saborowski R., Hagen W., Jeng M.-S., (2012) Metabolic energy demand and food utilization of the hydrothermal vent crab Xenograpsus testudinatus (Decapoda, Brachyura). Aquatic Biology, 15:11-25 
  • Stumpp, M.; Trübenbach, K.; Brennecke, D.; Hu, M.Y.; Melzner, F. (2012) Resource allocation and extracellular acid-base status in the sea urchin Strongylocentrotus droebachiensis in response to CO2 induced seawater acidification. Aquatic Toxicology, 110-111: 194-207 

2011

  • Hu M.Y., Tseng Y.-C., Lin L.-Y., Chen P.-Y.; Charmantier-Daures M., Hwang P. P., Melzner F. (2011) New insights into cephalopod ion regulation: a role of epidermal ionocytes in acid-base regulation during embryogenesis. American Journal of Physiology Regulatory and Integrative Physiology, 301: 1700-1709 
  • Hu, M.Y.; Tseng, Y.-C.; Stumpp, M.; Gutowska, M.; Kiko, R.; Lucassen, M.; Melzner, F. (2011) Elevated seawater pCO2 differentially affects branchial acid-base transporters over the course of development in the cephalopod Sepia officinalis. American Journal of Physiology Regulatory and Integrative Physiology, 300:R1100-R1114 

2010

  • Hu M.Y., Charmantier-Daures M., Charmantier G., Lucassen M., Sucre E., Melzner F., (2010) Localization of ion regulatory epithelia in embryos and hatchlings of two cephalopods. Cell and Tissue Research, 339:571-583

2009

  • Hu M.Y., Yan H.-Y., Chung W.-S., Shiao J.-C., Hwang P.-P., (2009) Acoustically evoked potentials in cephalopods inferred using the auditory brainstem response (ABR) approach. Comparative Biochemistry and Physiology-A, 153:278-83 Evaluated by Faculty of 1000 Biology